Computational-Based Mechanistic Study and Engineering of Cytochrome P450 MycG for Selective Oxidation of 16-Membered Macrolide Antibiotics-Reference-Cited by-同舟云学术

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Computational-Based Mechanistic Study and Engineering of Cytochrome P450 MycG for Selective Oxidation of 16-Membered Macrolide Antibiotics

Published:2020-10-08 Issue:42 Volume:142 Page:17981-17988
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Yang Song¹,DeMars Matthew D.²,Grandner Jessica M.¹^ORCID,Olson Noelle M.²,Anzai Yojiro³,Sherman David H.²⁴^ORCID,Houk K. N.¹^ORCID

Affiliation:

1. Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, United States

2. Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States

3. Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan

4. Departments of Medicinal Chemistry, Chemistry, and Microbiology & Immunology, University of Michigan, Ann Arbor, Michigan 48109, United States

Funder

Division of Chemistry

College of Pharmacy, University of Michigan

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.0c04388

Reference32 articles.

1. Hydrocarbon Hydroxylation by Cytochrome P450 Enzymes

2. Epoxidation of olefins by cytochrome P450: Evidence from site-specific mutagenesis for hydroperoxo-iron as an electrophilic oxidant

3. P450-Mediated Coupling of Indole Fragments To Forge Communesin and Unnatural Isomers

4. Identification of cytochrome P450 enzymes responsible forN-dealkylation of a new oral erectogenic, mirodenafil

5. IN VITRO SULFOXIDATION OF THIOETHER COMPOUNDS BY HUMAN CYTOCHROME P450 AND FLAVIN-CONTAINING MONOOXYGENASE ISOFORMS WITH PARTICULAR REFERENCE TO THE CYP2C SUBFAMILY

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2. A Mechanistic Understanding of the Distinct Regio‐ and Chemoselectivity of Multifunctional P450s by Structural Comparison of IkaD and CftA Complexed with Common Substrates;Angewandte Chemie;2023-11-14

3. Theoretical Study of Hydroxylation of α- and β-Pinene by a Cytochrome P450 Monooxygenase Model;International Journal of Molecular Sciences;2023-03-08

4. Molecular Dynamics Simulations Guide Chimeragenesis and Engineered Control of Chemoselectivity in Diketopiperazine Dimerases;Angewandte Chemie International Edition;2023-02-17

5. Molecular Dynamics Simulations Guide Chimeragenesis and Engineered Control of Chemoselectivity in Diketopiperazine Dimerases;Angewandte Chemie;2023-02-17

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