Conformational Restriction Approach to β-Secretase (BACE1) Inhibitors: Effect of a Cyclopropane Ring To Induce an Alternative Binding Mode-Reference-Cited by-同舟云学术

Conformational Restriction Approach to β-Secretase (BACE1) Inhibitors: Effect of a Cyclopropane Ring To Induce an Alternative Binding Mode

Published:2012-10-08 Issue:20 Volume:55 Page:8838-8858
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Yonezawa Shuji¹²,Yamamoto Takahiko³,Yamakawa Hidekuni³,Muto Chie³,Hosono Motoko³,Hattori Kazunari³,Higashino Kenichi¹,Yutsudo Takashi³,Iwamoto Hideo⁴,Kondo Yutaka⁴,Sakagami Masahiro³,Togame Hiroko⁵,Tanaka Yoshikazu¹,Nakano Toru¹,Takemoto Hiroshi³,Arisawa Mitsuhiro²,Shuto Satoshi²

Affiliation:

1. Shionogi Innovation Center for Drug Discovery, Shionogi & Co., Ltd., Kita-21 Nishi-11 Kita-ku, Sapporo 001-0021, Japan

2. Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan

3. Pharmaceutical Research Division, Medicinal Research Laboratories, and Innovative Drug Discovery Research Laboratories, Shionogi & Co., Ltd., 1-1, Futaba-cho 3-chome, Toyonaka, Osaka 561-0825, Japan

4. Shionogi Techno Advance Research Co., Ltd., 1-1, Futaba-cho 3-chome, Toyonaka, Osaka 561-0825, Japan

5. Quality, Safety and Regulatory Affairs Management Division, Shionogi & Co., Ltd., 1-8, Doshomachi 3-chome, Chuo-ku, Osaka 541-0045, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm3011405

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