Design, Synthesis, and Anti-inflammatory Properties of Orally Active 4-(Phenylamino)-pyrrolo[2,1-f][1,2,4]triazine p38α Mitogen-Activated Protein Kinase Inhibitors-Reference-Cited by-同舟云学术

Design, Synthesis, and Anti-inflammatory Properties of Orally Active 4-(Phenylamino)-pyrrolo[2,1-f][1,2,4]triazine p38α Mitogen-Activated Protein Kinase Inhibitors

Published:2007-12-12 Issue:1 Volume:51 Page:4-16
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hynes John¹,Dyckman Alaric J.¹,Lin Shuqun¹,Wrobleski Stephen T.¹,Wu Hong¹,Gillooly Kathleen M.¹,Kanner Steven B.¹,Lonial Herinder¹,Loo Derek¹,McIntyre Kim W.¹,Pitt Sidney¹,Shen Ding Ren¹,Shuster David J.¹,Yang XiaoXia¹,Zhang Rosemary¹,Behnia Kamelia¹,Zhang Hongjian¹,Marathe Punit H.¹,Doweyko Arthur M.¹,Tokarski John S.¹,Sack John S.¹,Pokross Matthew¹,Kiefer Susan E.¹,Newitt John A.¹,Barrish Joel C.¹,Dodd John¹,Schieven Gary L.¹,Leftheris Katerina¹

Affiliation:

1. Departments of Immunology Chemistry, Immunology Biology, Metabolism and Pharmacokinetics, and Molecular Biosciences, Bristol-Myers Squibb Pharmaceutical Research Institute, P.O. Box 4000, Princeton, New Jersey 08543-4000

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm7009414

Reference36 articles.

1. Cytokine Pathways and Joint Inflammation in Rheumatoid Arthritis

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4. Targeting IL-1 in inflammatory disease: new opportunities for therapeutic intervention

5. p38 Mitogen-Activated Protein Kinase (MAPK) in Rheumatoid Arthritis

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