Synthesis and Characterization of Triazine Derivatives as Important Heterocyclic Compounds and Study their Biological Activities

Abstract

Reaction 0f (thioacetamide/ acetemide) with chloroacetyl chloride to produced N-acetyl-2-chloro (thiocetamide/acetamide), then subsequent reaction with thiosemicarbazide to form N-acetyl-2-(2-carbamothioyl hydrazinyl)thioacetamide/acetamide. Ring closure or Cyclization of these compounds in the presence of sodium hydroxide yield N-(3-mercapto-1,4-dihydro-1,2,4 -triazin-5-yl)ethanethioamide/acetamide. The aim of this contribution is synthesis wide range of triazin derivatives by using different methodologies. These new triazine derivatives will be confirmed by FT- IR, 1HNMR, 13CNMR spectra. Since this triazine ring are very important core in chemical structure of some therapeutic compounds, will be evaluated for biological activities against two types of bacteria and fungi.