Development of Orally Bioavailable Peptides Targeting an Intracellular Protein: From a Hit to a Clinical KRAS Inhibitor
Author:
Affiliation:
1. Research Division, Chugai Pharmaceutical Co. Ltd., 216, Totsuka-cho, Totsuka-ku, Yokohama, Kanagawa 244-8602, Japan
Publisher
American Chemical Society (ACS)
Subject
Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis
Link
https://pubs.acs.org/doi/pdf/10.1021/jacs.3c03886
Reference39 articles.
1. Small molecules, big targets: drug discovery faces the protein–protein interaction challenge
2. Strategies for Targeting Protein-Protein Interactions With Synthetic Agents
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