Optimization of Chromone-2-carboxamide Melanin Concentrating Hormone Receptor 1 Antagonists: Assessment of Potency, Efficacy, and Cardiovascular Safety-Reference-Cited by-同舟云学术

Optimization of Chromone-2-carboxamide Melanin Concentrating Hormone Receptor 1 Antagonists: Assessment of Potency, Efficacy, and Cardiovascular Safety

Published:2006-09-29 Issue:22 Volume:49 Page:6569-6584
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Lynch John K.¹,Freeman Jennifer C.¹,Judd Andrew S.¹,Iyengar Rajesh¹,Mulhern Mathew¹,Zhao Gang¹,Napier James J.¹,Wodka Dariusz¹,Brodjian Sevan¹,Dayton Brian D.¹,Falls Doug¹,Ogiela Christopher¹,Reilly Regina M.¹,Campbell Thomas J.¹,Polakowski James S.¹,Hernandez Lisa¹,Marsh Kennan C.¹,Shapiro Robin¹,Knourek-Segel Victoria¹,Droz Brian¹,Bush Eugene¹,Brune Michael¹,Preusser Lee C.¹,Fryer Ryan M.¹,Reinhart Glenn A.¹,Houseman Kathryn¹,Diaz Gilbert¹,Mikhail Ann¹,Limberis James T.¹,Sham Hing L.¹,Collins Christine A.¹,Kym Philip R.¹

Affiliation:

1. Metabolic Disease Research, Integrative Pharmacology, Process Chemistry, and Exploratory Pharmacokinetics, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm060683e

Reference25 articles.

1. Melanin-concentrating Hormone Receptor: An Orphan Receptor Fits the Key

2. Central nervous system control of food intake

3. Acute and chronic administration of melanin-concentrating hormone enhances food intake and body weight in Wistar and Sprague–Dawley rats

4. Chronic intracerebroventricular infusion of MCH causes obesity in mice

5. Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance

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