Design of a Conformationally Restricted Analogue of the Antiepilepsy Drug Vigabatrin that Directs Its Mechanism of Inactivation of γ-Aminobutyric Acid Aminotransferase

Author:

Choi Sun1,Storici Paola1,Schirmer Tilman1,Silverman Richard B.1

Affiliation:

1. Contribution from the Department of Chemistry and Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, Illinois 60208-3113, and Division of Structural Biology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Reference25 articles.

1. Chemical Nature of Synaptic Transmission in Vertebrates

2. GABA in Epilepsy: The Pharmacologic Basis

3. Hornykiewicz, O.; Lloyd, K. B.; Davidson, L. InGABA in NervousSystem Function; Roberts, E., Chase, T. N., Tower, D. B., Eds.; Raven Press:  New York, 1976; pp 479−485.

4. Huntington's Chorea

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