1. Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Faculty of Medicine, Imperial College London, South Kensington, London SW7 2AZ, UK, Bruker BioSpin GmbH, Silberstreifen, D-76287 Rheinstetten, Germany, and Department of Drug Metabolism, Division of Pharmacokinetics & Metabolism, Servier Research & Development Ltd., Rowley, Wexham Springs, Framewood Road, Wexham, Slough, SL3 6PJ, UK