Synthesis of BACE Inhibitor LY2886721. Part I. An Asymmetric Nitrone Cycloaddition Strategy
Author:
Affiliation:
1. Small Molecule Design and Development, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, United States
2. Dottikon Exclusive Synthesis AG, P.O. Box 5605, Dottikon, Switzerland
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/op500351q
Reference40 articles.
1. The Potent BACE1 Inhibitor LY2886721 Elicits Robust Central A Pharmacodynamic Responses in Mice, Dogs, and Humans
2. bMergott, D. J.; Vaught, G. M.BACE Inhibitors, US 2012/8278441.
3. A simple oxime–nitrone isomerisation and intramolecular nitrone-cycloaddition reaction of 3-(alk-2-enylamino)propionaldehyde oximes
4. Large-Scale Continuous Flow Transformation of Oximes into Fused-Bicyclic Isoxazolidines: An Example of Process Intensification
5. Synthesis of BACE Inhibitor LY2886721. Part II. Isoxazolidines as Precursors to Chiral Aminothiazines, Selective Peptide Coupling, and a Controlled Reactive Crystallization
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