Cumulative complexity meta-metrics as an efficiency measure and predictor of process mass intensity (PMI) during synthetic route design-Reference-Cited by-同舟云学术

Cumulative complexity meta-metrics as an efficiency measure and predictor of process mass intensity (PMI) during synthetic route design

Published:2023 Issue:14 Volume:25 Page:5543-5556
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Angelini Lucrezia¹^ORCID,Coomber Charlotte E.¹^ORCID,Howell Gareth P.¹^ORCID,Karageorgis George¹^ORCID,Taylor Brian A.¹

Affiliation:

1. Chemical Development, Pharmaceutical Technology & Development, Operations, AstraZeneca, Macclesfield SK10 2NA, UK

Abstract

Functioning as a surrogate for step count, a cumulative complexity meta-metric (∑CM*), calculated along the longest linear sequence of a synthetic route, is demonstrated to be a useful predictor of process mass intensity (PMI).

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/GC/D3GC00878A

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