Discovery of 2-(2-Chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one (PF-514273), a Novel, Bicyclic Lactam-Based Cannabinoid-1 Receptor Antagonist for the Treatment of Obesity-Reference-Cited by-同舟云学术

Discovery of 2-(2-Chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one (PF-514273), a Novel, Bicyclic Lactam-Based Cannabinoid-1 Receptor Antagonist for the Treatment of Obesity

Published:2009-04-07 Issue:9 Volume:52 Page:2652-2655
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Dow Robert L.¹,Carpino Philip A.¹,Hadcock John R.¹,Black Shawn C.¹,Iredale Philip A.¹,DaSilva-Jardine Paul¹,Schneider Steven R.¹,Paight Ernest S.¹,Griffith David A.¹,Scott Dennis O.¹,O’Connor Rebecca E.¹,Nduaka Chudy I.¹

Affiliation:

1. Departments of Cardiovascular, Metabolic and Endocrine Diseases, Neuroscience, and Drug Safety, Pfizer Global Research and Development, Groton, Connecticut 06340

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm900255t

Reference22 articles.

1. Adipose Tissue as an Endocrine Organ

2. Endocannabinoids in the regulation of appetite and body weight

3. The Emerging Role of the Endocannabinoid System in Endocrine Regulation and Energy Balance

4. Regulation, Function, and Dysregulation of Endocannabinoids in Models of Adipose and β-Pancreatic Cells and in Obesity and Hyperglycemia

5. Low dose anandamide affects food intake, cognitive function, neurotransmitter and corticosterone levels in diet-restricted mice

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