Quantum Mechanical/Molecular Mechanical Investigation of the Mechanism of C−H Hydroxylation of Camphor by Cytochrome P450cam: Theory Supports a Two-State Rebound Mechanism-Reference-Cited by-同舟云学术

Quantum Mechanical/Molecular Mechanical Investigation of the Mechanism of C−H Hydroxylation of Camphor by Cytochrome P450cam: Theory Supports a Two-State Rebound Mechanism

Published:2004-03-01 Issue:12 Volume:126 Page:4017-4034
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Schöneboom Jan C.¹,Cohen Shimrit¹,Lin Hai¹,Shaik Sason¹,Thiel Walter¹

Affiliation:

1. Contribution from the Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, D-45470 Mülheim an der Ruhr, Germany, and the Department of Organic Chemistry and the Lise Meitner Center for Computational Quantum Chemistry, The Hebrew University, 91904 Jerusalem, Israel

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja039847w

Reference98 articles.

1. Cytochrome P450

2. Reactive iron porphyrin derivatives related to the catalytic cycles of cytochrome P-450 and peroxidase. Studies of the mechanism of oxygen activation

3. Hydroxylation of Camphor by Reduced Oxy-Cytochrome P450cam: Mechanistic Implications of EPR and ENDOR Studies of Catalytic Intermediates in Native and Mutant Enzymes

4. Aliphatic hydroxylation via oxygen rebound. Oxygen transfer catalyzed by iron

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