Impact of Polymer Type and Relative Humidity on the Long-Term Physical Stability of Amorphous Solid Dispersions-Reference-Cited by-同舟云学术

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Impact of Polymer Type and Relative Humidity on the Long-Term Physical Stability of Amorphous Solid Dispersions

Published:2017-11-07 Issue:12 Volume:14 Page:4374-4386
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Lehmkemper Kristin¹²^ORCID,Kyeremateng Samuel O.¹,Heinzerling Oliver¹,Degenhardt Matthias¹,Sadowski Gabriele²^ORCID

Affiliation:

1. Global Pharmaceutical R&D, AbbVie Deutschland GmbH & Co. KG, Knollstraße, D-67061 Ludwigshafen am Rhein, Germany

2. Laboratory of Thermodynamics, Department of Biochemical and Chemical Engineering, TU Dortmund, Emil-Figge-Straße 70, D-44227 Dortmund, Germany

Funder

AbbVie

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.7b00492

Reference56 articles.

1. Improving drug solubility for oral delivery using solid dispersions

2. Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs

3. Pharmaceutical Applications of Solid Dispersion Systems

4. Solubility advantage of amorphous pharmaceuticals: I. A thermodynamic analysis

5. Predicting the Solubility Advantage of Amorphous Pharmaceuticals: A Novel Thermodynamic Approach

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