Predicting the Solubility Advantage of Amorphous Pharmaceuticals: A Novel Thermodynamic Approach
Author:
Affiliation:
1. TU Dortmund, Department of Biochemical and Chemical Engineering, Laboratory of Thermodynamics, Emil-Figge Straße 70, D-44227 Dortmund, Germany
Funder
Alexander von Humboldt-Stiftung
Deutsche Forschungsgemeinschaft
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Pharmaceutical Science,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/mp500824d
Reference45 articles.
1. Some Pharmaceutical Properties of Novobiocin **Received August 21, 1959, from Merck Sharp and Dohme Research Laboratories, West Point, Pa.
2. Stability and several physical properties of amorphous and crystalline forms of indomethacin.
3. Solubility Advantage of Amorphous Pharmaceuticals, Part 3: Is Maximum Solubility Advantage Experimentally Attainable and Sustainable?
4. Solubility Advantage of Amorphous Pharmaceuticals: II. Application of Quantitative Thermodynamic Relationships for Prediction of Solubility Enhancement in Structurally Diverse Insoluble Pharmaceuticals
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