Investigating the Orientation of an Interfacially Adsorbed Monoclonal Antibody and Its Fragments Using Neutron Reflection-Reference-Cited by-同舟云学术

Investigating the Orientation of an Interfacially Adsorbed Monoclonal Antibody and Its Fragments Using Neutron Reflection

Published:2023-02-16 Issue:3 Volume:20 Page:1643-1656
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Ruane Sean¹,Li Zongyi¹^ORCID,Hollowell Peter¹,Hughes Arwel²,Warwicker Jim³^ORCID,Webster John R. P.²,van der Walle Christopher F.⁴^ORCID,Kalonia Cavan⁵,Lu Jian R.¹^ORCID

Affiliation:

1. Biological Physics Laboratory, School of Physics and Astronomy, University of Manchester, Oxford Road, Schuster Building, Manchester M13 9PL, U.K.

2. ISIS Neutron Facility, STFC, Chilton, Didcot OX11 0QZ, U.K.

3. Division of Molecular and Cellular Function, Manchester Institute of Biotechnology, University of Manchester, Oxford Road, Manchester M13 9PL, U.K.

4. Dosage Form Design and Development, Biopharmaceutical Development, AstraZeneca, Cambridge CB21 6GH, U.K.

5. Dosage Form Design and Development, AstraZeneca, Gaithersburg, Maryland 20878, United States

Funder

AstraZeneca

Engineering and Physical Sciences Research Council

Innovate UK

H2020 Marie Sklodowska-Curie Actions

Biotechnology and Biological Sciences Research Council

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine