Physicochemical Stability of the Antibody−Drug Conjugate Trastuzumab-DM1: Changes due to Modification and Conjugation Processes-Reference-Cited by-同舟云学术

Physicochemical Stability of the Antibody−Drug Conjugate Trastuzumab-DM1: Changes due to Modification and Conjugation Processes

Published:2010-08-10 Issue:9 Volume:21 Page:1588-1595
ISSN:1043-1802
Container-title:Bioconjugate Chemistry
language:en
Short-container-title:Bioconjugate Chem.

Author:

Wakankar Aditya A.¹,Feeney Maria B.¹,Rivera Javier¹,Chen Yan¹,Kim Michael¹,Sharma Vikas K.¹,Wang Y. John¹

Affiliation:

1. Late Stage Pharmaceutical and Processing Development, Early Stage Pharmaceutical Development, and Protein and Analytical Chemistry, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, and Department of Pharmaceutical Chemistry, The University of Kansas, 2095 Constant Avenue, Lawrence, Kansas 66047

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology

Link

https://pubs.acs.org/doi/pdf/10.1021/bc900434c

Reference20 articles.

1. Targeted delivery of chemotherapeutics: tumor-activated prodrug therapy

2. Targeted Cancer Therapy: Conferring Specificity to Cytotoxic Drugs

3. Antibody-Maytansinoid Conjugates Are Activated in Targeted Cancer Cells by Lysosomal Degradation and Linker-Dependent Intracellular Processing

4. Progress in immunoconjugate cancer therapeutics

5. Arming antibodies: prospects and challenges for immunoconjugates

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