Guiding Lead Optimization for Solubility Improvement with Physics-Based Modeling-Reference-Cited by-同舟云学术

Guiding Lead Optimization for Solubility Improvement with Physics-Based Modeling

Published:2020-01-23 Issue: Volume: Page:
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Abramov Yuriy A.¹²^ORCID,Sun Guangxu³,Zeng Qiao³,Zeng Qun³,Yang Mingjun³

Affiliation:

1. XtalPi Inc, 245 Main Street, Cambridge, Massachusetts 02142, United States

2. Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, United States

3. XtalPi Inc., Shenzhen Jingtai Technology Co., Ltd., Floor 4, No. 9, Hualian Industrial Zone, Dalang Street, Longhua District, Shenzhen 518100, China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.9b01138

Reference51 articles.

1. Drug-Like Property Concepts in Pharmaceutical Design

2. Optimizing solubility: Kinetic versus thermodynamic solubility temptations and risks

3. Oral Absorption of Poorly Water-Soluble Drugs: Computer Simulation of Fraction Absorbed in Humans from a Miniscale Dissolution Test

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