Mechanism of Binding of Antifungal Antibiotic Amphotericin B to Lipid Membranes: An Insight from Combined Single-Membrane Imaging, Microspectroscopy, and Molecular Dynamics-Reference-Cited by-同舟云学术

Mechanism of Binding of Antifungal Antibiotic Amphotericin B to Lipid Membranes: An Insight from Combined Single-Membrane Imaging, Microspectroscopy, and Molecular Dynamics

Published:2018-08-06 Issue:9 Volume:15 Page:4202-4213
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Grela Ewa¹²,Wieczór Miłosz³,Luchowski Rafał¹,Zielinska Joanna⁴,Barzycka Angelika¹,Grudzinski Wojciech¹,Nowak Katarzyna⁵,Tarkowski Piotr⁶,Czub Jacek³^ORCID,Gruszecki Wieslaw I.¹^ORCID

Affiliation:

1. Department of Biophysics, Institute of Physics, Maria Curie-Sklodowska University, 20-031 Lublin, Poland

2. Department of Biophysics, Institute of Biology, Maria Curie-Sklodowska University, 20-031 Lublin, Poland

3. Department of Physical Chemistry, Gdansk University of Technology, 80-233 Gdansk, Poland

4. Department of Pharmaceutical Chemistry, Medical University of Gdansk, 80-416 Gdansk, Poland

5. Department of Natural Environment Biogeochemistry, Institute of Agrophysics, Polish Academy of Sciences, 20-290 Lublin, Poland

6. Medical University of Lublin, 20-059 Lublin, Poland

Funder

Narodowe Centrum Nauki

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.8b00572

Reference41 articles.

1. Amphotericin B Formulations: A Comparative Review of Efficacy and Toxicity

2. Toxicity of Amphotericin B Deoxycholate-Based Induction Therapy in Patients with HIV-Associated Cryptococcal Meningitis

3. Our Path to Less Toxic Amphotericins

4. The Viscoelastic Properties of the Fungal Cell Wall Allow Traffic of AmBisome as Intact Liposome Vesicles

5. Design of amphotericin B oral formulation for antifungal therapy

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