P-glycoprotein, CYP3A, and Plasma Carboxylesterase Determine Brain Disposition and Oral Availability of the Novel Taxane Cabazitaxel (Jevtana) in Mice

Author:

Tang Seng Chuan1,Kort Anita12,Cheung Ka Lei3,Rosing Hilde2,Fukami Tatsuki4,Durmus Selvi1,Wagenaar Els1,Hendrikx Jeroen J. M. A.2,Nakajima Miki4,van Vlijmen Bart J. M.3,Beijnen Jos H.25,Schinkel Alfred H.1

Affiliation:

1. Department of Molecular Oncology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands

2. Department of Pharmacy and Pharmacology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek, 1066 CX Amsterdam, The Netherlands

3. Department of Thrombosis and Hemostasis, Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands

4. Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan

5. Division of Pharmacoepidemiology and Clinical Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3512 JE Utrecht, The Netherlands

Funder

KWF Kankerbestrijding

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Reference42 articles.

1. Update on taxane development: new analogs and new formulations

2. Multidrug resistance in cancer: role of ATP–dependent transporters

3. Docetaxel and Estramustine Compared with Mitoxantrone and Prednisone for Advanced Refractory Prostate Cancer

4. Drug resistance in metastatic castration-resistant prostate cancer

5. Center for Drug Evaluation and Research of the US Department of Health and Human Services. Clinical Pharmacology and Biopharmaceutics Review(s): Jevtana, 2010.http://www.accessdata.fda.gov/drugsatfda_docs/nda/2010/201023s000ClinPharmR.pdf(accessed February 13, 2015).

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