An in Vitro Assay Using Cultured Kupffer Cells Can Predict the Impact of Drug Conjugation on in Vivo Antibody Pharmacokinetics-Reference-Cited by-同舟云学术

An in Vitro Assay Using Cultured Kupffer Cells Can Predict the Impact of Drug Conjugation on in Vivo Antibody Pharmacokinetics

Published:2020-01-24 Issue:3 Volume:17 Page:802-809
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Meyer David W¹^ORCID,Bou Lauren B¹,Shum Sara¹,Jonas Mechthild¹,Anderson Martha E¹,Hamilton Joe Z¹,Hunter Joshua H¹,Wo Serena W¹,Wong Abbie O¹,Okeley Nicole M¹,Lyon Robert P¹

Affiliation:

1. Seattle Genetics, Inc., 21823 30th Dr SE Bothell, Washington 98021, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.9b00991

Reference37 articles.

1. Antibodies to watch in 2019

2. Pharmacokinetics of monoclonal antibodies and Fc-fusion proteins

3. Key factors influencing ADME properties of therapeutic proteins: A need for ADME characterization in drug discovery and development

4. FcRn: the neonatal Fc receptor comes of age

5. Antibody drug conjugates: Progress, pitfalls, and promises

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