Insights into the Dissolution Behavior of Ledipasvir–Copovidone Amorphous Solid Dispersions: Role of Drug Loading and Intermolecular Interactions-Reference-Cited by-同舟云学术

Insights into the Dissolution Behavior of Ledipasvir–Copovidone Amorphous Solid Dispersions: Role of Drug Loading and Intermolecular Interactions

Published:2019-11-05 Issue:12 Volume:16 Page:5054-5067
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Que Chailu¹,Lou Xiaochun²,Zemlyanov Dmitry Y.³,Mo Huaping⁴,Indulkar Anura S.²,Gao Yi⁵,Zhang Geoff G. Z.²,Taylor Lynne S.¹^ORCID

Affiliation:

1. Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States

2. Drug Product Development, Research and Development, AbbVie Inc., North Chicago, Illinois 60064, United States

3. Birck Nanotechnology Center, Purdue University, West Lafayette, Indiana 47907, United States

4. Purdue Interdepartmental NMR Facility, Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States

5. Science and Technology, Operations, AbbVie Inc., North Chicago, Illinois 60064, United States

Funder

AbbVie

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.9b01025

Reference41 articles.

1. Pharmaceutical applications of cyclodextrins: basic science and product development

2. Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs

3. Strategies to Address Low Drug Solubility in Discovery and Development

4. Assessment of the Amorphous “Solubility” of a Group of Diverse Drugs Using New Experimental and Theoretical Approaches

5. Assessing the performance of amorphous solid dispersions

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