Chemical Site-Specific Conjugation Platform to Improve the Pharmacokinetics and Therapeutic Index of Antibody

Chemical Site-Specific Conjugation Platform to Improve the Pharmacokinetics and Therapeutic Index of Antibody–Drug Conjugates

Published:2021-09-28 Issue:11 Volume:18 Page:4058-4066
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Matsuda Yutaka¹²^ORCID,Seki Takuya¹,Yamada Kei¹^ORCID,Ooba Yuri¹,Takahashi Kazutoshi¹^ORCID,Fujii Tomohiro¹,Kawaguchi Sayaka¹,Narita Takahiro¹,Nakayama Akira¹,Kitahara Yoshiro¹,Mendelsohn Brian A.²^ORCID,Okuzumi Tatsuya¹^ORCID

Affiliation:

1. Ajinomoto Co., Inc., 1-1, Suzuki-Cho, Kawasaki-Ku, Kawasaki-Shi, Kanagawa 210-8681, Japan

2. Ajinomoto Bio-Pharma Services, 11040 Roselle Street, San Diego, California 92121, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.1c00473

Reference31 articles.

1. Paul Ehrlich's magic bullet concept: 100 years of progress

2. Antibody Conjugates-Recent Advances and Future Innovations

3. Antibody–Drug Conjugates: A Comprehensive Review

4. Recent Advances in Drug–Antibody Ratio Determination of Antibody–Drug Conjugates

5. Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

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