In Silico Modeling Approach for the Evaluation of Gastrointestinal Dissolution, Supersaturation, and Precipitation of Posaconazole-Reference-Cited by-同舟云学术

In Silico Modeling Approach for the Evaluation of Gastrointestinal Dissolution, Supersaturation, and Precipitation of Posaconazole

Published:2017-09-05 Issue:12 Volume:14 Page:4321-4333
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Hens Bart¹²^ORCID,Pathak Shriram M.³^ORCID,Mitra Amitava⁴⁵,Patel Nikunjkumar³,Liu Bo³,Patel Sanjaykumar⁶,Jamei Masoud³,Brouwers Joachim²,Augustijns Patrick²^ORCID,Turner David B.³

Affiliation:

1. College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109-1065, United States of America

2. Drug Delivery & Disposition, KU Leuven, Leuven 3000, Belgium

3. Simcyp Limited (a Certara Company), Sheffield S2 4SU, United Kingdom

4. Biopharmaceutics, Pharmaceutical Sciences & Clinical Supply, Merck & Co., Inc., West Point, Pennsylvania 19486, United States of America

5. Sandoz, Inc., West Princeton, New Jersey 08540, United States of America

6. Analytical Sciences, Pharmaceutical Sciences & Clinical Supply, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States of America

Funder

FP7 Joint Technology Initiatives

Agentschap voor Innovatie door Wetenschap en Technologie

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.7b00396

Reference39 articles.

1. BCS Biowaivers: Similarities and Differences Among EMA, FDA, and WHO Requirements

2. Low Buffer Capacity and Alternating Motility along the Human Gastrointestinal Tract: Implications for in Vivo Dissolution and Absorption of Ionizable Drugs

3. In vitro models for the prediction of in vivo performance of oral dosage forms

4. Evaluation of gastrointestinal drug supersaturation and precipitation: Strategies and issues

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