Ionizable Drug Self-Associations and the Solubility Dependence on pH: Detection of Aggregates in Saturated Solutions Using Mass Spectrometry (ESI-Q-TOF-MS/MS)-Reference-Cited by-同舟云学术

Ionizable Drug Self-Associations and the Solubility Dependence on pH: Detection of Aggregates in Saturated Solutions Using Mass Spectrometry (ESI-Q-TOF-MS/MS)

Published:2021-05-13 Issue:6 Volume:18 Page:2311-2321
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Fuguet Elisabet¹²^ORCID,Subirats Xavier¹^ORCID,Ràfols Clara¹^ORCID,Bosch Elisabeth¹,Avdeef Alex³

Affiliation:

1. Departament d’Enginyeria Química i Química Analítica and Institut de Biomedicina (IBUB), Universitat de Barcelona, Martí i Franquès 1-11, Barcelona E-08028, Spain

2. Serra-Húnter Program, Generalitat de Catalunya, Barcelona E-08028, Spain

3. in-ADME Research, 1732 First Avenue #102, New York 10128, New York, United States

Funder

Ministerio de Econom?a, Industria y Competitividad, Gobierno de Espa?a

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.1c00131

Reference37 articles.

1. Study of pH-dependent solubility of organic bases. Revisit of Henderson-Hasselbalch relationship