The Rat Continuous Intestine Model Predicts the Impact of Particle Size and Transporters on the Oral Absorption of Glyburide-Reference-Cited by-同舟云学术

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The Rat Continuous Intestine Model Predicts the Impact of Particle Size and Transporters on the Oral Absorption of Glyburide

Published:2022-12-21 Issue:1 Volume:20 Page:219-231
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Nagar Swati¹^ORCID,Radice Casey¹,Tuohy Robert²,Stevens Raymond³,Bennyhoff Dale³,Korzekwa Ken¹^ORCID

Affiliation:

1. Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, Pennsylvania19140, United States

2. Pace Analytical Life Sciences LLC, Norristown, Pennsylvania19401, United States

3. Particle Solutions LLC, West Chester, Pennsylvania19382, United States

Funder

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.2c00597

Reference58 articles.

1. Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network

2. Impact of gastrointestinal disease states on oral drug absorption – implications for formulation design – a PEARRL review

3. A pharmacoscintigraphic evaluation of oral budesonide given as controlled-release (Entocort) capsules

4. Sex Differences in Intestinal P-Glycoprotein Expression in Wistar versus Sprague Dawley Rats

5. Quantification of P-Glycoprotein in the Gastrointestinal Tract of Humans and Rodents: Methodology, Gut Region, Sex, and Species Matter

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1. Disposition of Oral Nalbuphine and Its Metabolites in Healthy Subjects and Subjects with Hepatic Impairment: Preliminary Modeling Results Using a Continuous Intestinal Absorption Model with Enterohepatic Recirculation;Metabolites;2024-08-27

2. A Continuous Intestinal Absorption Model to Predict Drug Enterohepatic Recirculation in Healthy Humans: Nalbuphine as a Model Substrate;Molecular Pharmaceutics;2024-07-03

3. Assessing and mitigating pH-mediated DDI risks in drug development – formulation approaches and clinical considerations;Drug Metabolism Reviews;2024-05-03

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