Quantification of P-Glycoprotein in the Gastrointestinal Tract of Humans and Rodents: Methodology, Gut Region, Sex, and Species Matter-Reference-Cited by-同舟云学术

Quantification of P-Glycoprotein in the Gastrointestinal Tract of Humans and Rodents: Methodology, Gut Region, Sex, and Species Matter

Published:2021-04-22 Issue:5 Volume:18 Page:1895-1904
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Mai Yang¹²,Dou Liu¹²,Yao Zhicheng³,Madla Christine M.¹,Gavins Francesca K. H.¹,Taherali Farhan¹,Yin Heyue²,Orlu Mine¹,Murdan Sudaxshina¹,Basit Abdul W.¹^ORCID

Affiliation:

1. UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, U.K.

2. School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Guangzhou 510275, China

3. Department of General Surgery, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China

Funder

Engineering and Physical Sciences Research Council

Ministry of Education of the People's Republic of China

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.0c00574

Reference54 articles.

1. Impact of regional differences along the gastrointestinal tract of healthy adults on oral drug absorption: An UNGAP review

2. P-glycoprotein: from genomics to mechanism

3. Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

4. Protein Abundance of Clinically Relevant Multidrug Transporters along the Entire Length of the Human Intestine

5. Segmental Dependent Transport of Low Permeability Compounds along the Small Intestine Due to P-Glycoprotein: The Role of Efflux Transport in the Oral Absorption of BCS Class III Drugs

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