Mechanism of Supersaturation Suppression in Dissolution Process of Acidic Drug Salt

Author:

Oki Jumpei1,Watanabe Daiju1,Uekusa Taiga1,Sugano Kiyohiko1ORCID

Affiliation:

1. Molecular Pharmaceutics Lab, College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1, Noji-higashi, Kusatsu, Shiga 525-8577, Japan

Funder

Japan Agency for Medical Research and Development

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Reference43 articles.

1. Solubility and Dissolution Profile Assessment in Drug Discovery

2. FINDING SOLUTIONS

3. Salt formation to improve drug solubility

4. Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates

5. Nichi-Iko Pharmaceutical Co., Ltd. Diclofenac Sodium Drug Product Information; December 26, 2018. https://www.nichiiko.co.jp/medicine/file/38800/elution/38800_elution.pdf.

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