Susceptibility of Antibody CDR Residues to Chemical Modifications Can Be Revealed Prior to Antibody Humanization and Aid in the Lead Selection Process-Reference-Cited by-同舟云学术

Susceptibility of Antibody CDR Residues to Chemical Modifications Can Be Revealed Prior to Antibody Humanization and Aid in the Lead Selection Process

Published:2018-08-17 Issue:10 Volume:15 Page:4529-4537
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Xu Ankai,Kim Hok Seon,Estee Samarkand,ViaJar Sharon,Galush William J.,Gill Avinash,Hötzel Isidro,Lazar Greg A.,McDonald Paul,Andersen Nisana,Spiess Christoph^ORCID

Funder

Genentech

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.8b00536

Reference23 articles.

1. Assessment of chemical modifications of sites in the CDRs of recombinant antibodies

2. Current progress in innovative engineered antibodies

3. The immunogenicity of humanized and fully human antibodies

4. Development trends for human monoclonal antibody therapeutics

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