Drug-Excipient Interactions: Effect on Molecular Mobility and Physical Stability of Ketoconazole–Organic Acid Coamorphous Systems
Author:
Affiliation:
1. Department of Pharmaceutics, University of Minnesota, Minneapolis, Minnesota 55455, United States
2. Department of Chemistry, Macalester College, Saint Paul, Minnesota 55105, United States
Funder
Pharmaceutical Research and Manufacturers of America Foundation
University of Minnesota
William and Mildred Peters Endowment Fund
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Pharmaceutical Science,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.7b00932
Reference24 articles.
1. Ability of Polyvinylpyrrolidone and Polyacrylic Acid to Inhibit the Crystallization of Amorphous Acetaminophen
2. Role of the Strength of Drug–Polymer Interactions on the Molecular Mobility and Crystallization Inhibition in Ketoconazole Solid Dispersions
3. Strength of Drug–Polymer Interactions: Implications for Crystallization in Dispersions
4. Drug–Polymer Solubility and Miscibility: Stability Consideration and Practical Challenges in Amorphous Solid Dispersion Development
5. Application of Melt Extrusion in the Development of a Physically and Chemically Stable High-Energy Amorphous Solid Dispersion of a Poorly Water-Soluble Drug
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