Catalytic Reaction Mechanism for Drug Metabolism in Human Carboxylesterase-1: Cocaine Hydrolysis Pathway
Author:
Affiliation:
1. School of Biological Science and Techonology, University of Jinan, Jinan 250022, China
2. School of Medicine, Hangzhou Normal University, Hangzhou 311121, China
Funder
Division of Chemistry
National Institute on Drug Abuse
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Pharmaceutical Science,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.8b00354
Reference61 articles.
1. Modifications of human carboxylesterase for improved prodrug activation
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4. Conventional liquid chromatography/triple quadrupole mass spectrometry based metabolite identification and semi-quantitative estimation approach in the investigation of in vitro dabigatran etexilate metabolism
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