Potent Antagonists of RORγt, Cardenolides from Calotropis gigantea, Exhibit Discrepant Effects on the Differentiation of T Lymphocyte Subsets-Reference-Cited by-同舟云学术

Potent Antagonists of RORγt, Cardenolides from Calotropis gigantea, Exhibit Discrepant Effects on the Differentiation of T Lymphocyte Subsets

Published:2018-12-28 Issue:2 Volume:16 Page:798-807
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Liu Juan¹,Bai Li-Ping¹,Yang Fen¹,Yao Xiaojun¹,Lei Kawai¹,Kei Lam Christopher Wai¹,Wu Qibiao¹,Zhuang Yuxin¹,Xiao Riping¹,Liao Kangsheng¹,Kuok Hioha¹,Li Ting¹^ORCID,Liu Liang¹

Affiliation:

1. State Key Laboratory of Quality Research in Chinese Medicines, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau 999078, People’s Republic of China

Funder

Fundo para o Desenvolvimento das Ci?ncias e da Tecnologia

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.8b01063

Reference34 articles.

1. Upstream Stimulating Factors Regulate the Expression of RORγT in Human Lymphocytes

2. The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

3. Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity