Affiliation:
1. CAS Key Laboratory of Tropical Plant Resources and Sustainable Use Xishuangbanna Tropical Botanical Garden Chinese Academy of Sciences Kunming 650223 China
2. State Key Laboratory of Quality Research in Chinese Medicines Macau Institute for Applied Research in Medicine and Health Macau University of Science and Technology Macau 999078 China
3. Industrial Crop Research Institute Yunnan Academy of Agricultural Sciences Kunming 650223 China
Abstract
AbstractChemical investigation of medicinal plant Glycosmis lucida Wall. ex C. C. Huang leaves led to the production of ten compounds (1–10), including two previously unreported geranylated sulfur‐containing amides (1 and 2) and eight known ones (3–10). Structural characterization was carried out using comprehensive spectroscopic methods including NMR, MS and CD. The inhibitory effects of all isolates on Th17 differentiation were evaluated, of which compounds 1 and 6 significantly inhibited Th17 differentiation with IC50 values of 0.36 and 1.30 μM, respectively, while both 1 and 6 failed to bind to retinoic acid‐related orphan receptor gamma t (RORγt), suggesting that their inhibition of Th17 differentiation is independent of RORγt.
Funder
National Natural Science Foundation of China
Subject
Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering
Cited by
2 articles.
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