Physiologically Based Pharmacokinetic Modeling in Lead Optimization. 2. Rational Bioavailability Design by Global Sensitivity Analysis To Identify Properties Affecting Bioavailability-Reference-Cited by-同舟云学术

Physiologically Based Pharmacokinetic Modeling in Lead Optimization. 2. Rational Bioavailability Design by Global Sensitivity Analysis To Identify Properties Affecting Bioavailability

Published:2018-01-16 Issue:3 Volume:15 Page:831-839
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Daga Pankaj R.¹^ORCID,Bolger Michael B.²,Haworth Ian S.³,Clark Robert D.²,Martin Eric J.¹^ORCID

Affiliation:

1. Novartis Institute of Biomedical Research, Emeryville, California 94608, United States

2. Simulations Plus, Inc., 42505 10th Street West, Lancaster, California 93534, United States

3. Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, California 90089, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.7b00973

Reference27 articles.

1. A Real-World Perspective on Molecular Design

2. Working with Small Molecules: Rules-of-Thumb of “Drug Likeness”

3. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1

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