Development of a 2D-QSAR Model for Tissue-to-Plasma Partition Coefficient Value with High Accuracy Using Machine Learning Method, Minimum Required Experimental Values, and Physicochemical Descriptors

Author:

Handa KoichiORCID,Sakamoto Seishiro,Kageyama Michiharu,Iijima Takeshi

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology

Reference55 articles.

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3. US Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER). Physiologically Based Pharmacokinetic Analyses—Format and Content Guidance for Industry. 2019.

4. EMA. Reporting of physiologically based pharmacokinetic (PBPK) modelling and simulation. European Medicines Agency. 2018. https://www.ema.europa.eu/en/reporting-physiologically-based-pharmacokinetic-pbpk-modelling-simulation-scientific-guideline. Accessed 10 Apr 2023.

5. Shebley M, Sandhu P, Emami Riedmaier A, Jamei M, Narayanan R, Patel A, et al. Physiologically based pharmacokinetic model qualification and reporting procedures for regulatory submissions: a consortium perspective. Clin Pharmacol Ther. 2018;104(1):88–110.

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