Metabolism of a Bioorthogonal PET Tracer Candidate [19F/18F]SiFA-Tetrazine in Mouse Liver Microsomes: Biotransformation Pathways and Defluorination Investigated by UHPLC-HRMS-Reference-Cited by-同舟云学术

Metabolism of a Bioorthogonal PET Tracer Candidate [19F/18F]SiFA-Tetrazine in Mouse Liver Microsomes: Biotransformation Pathways and Defluorination Investigated by UHPLC-HRMS

Published:2020-06-15 Issue:8 Volume:17 Page:3106-3115
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Otaru Sofia¹^ORCID,Niemikoski Hanna²^ORCID,Sarparanta Mirkka¹^ORCID,Airaksinen Anu J.¹³^ORCID

Affiliation:

1. Radiochemistry, Department of Chemistry, University of Helsinki, 00014 Helsinki, Finland

2. Finnish Institute for Verification of the Chemical Weapons Convention (VERIFIN), Department of Chemistry, University of Helsinki, 00014 Helsinki, Finland

3. Turku PET Centre, Department of Chemistry, University of Turku, 20500 Turku, Finland

Funder

Academy of Finland

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.0c00523

Reference52 articles.

1. Positron Emission Tomography: Current Challenges and Opportunities for Technological Advances in Clinical and Preclinical Imaging Systems

2. The importance of small polar radiometabolites in molecular neuroimaging: A PET study with [11C]Cimbi-36 labeled in two positions