A Concise and Unified Strategy for Synthesis of the C1–C18 Macrolactone Fragments of FD-891, FD-892 and Their Analogues: Formal Total Synthesis of FD-891
Author:
Affiliation:
1. Graduate School of Pharmaceutical Sciences and ‡Research and Analytical Center for Giant Molecules, Graduate School of Science, Tohoku University, 6-3 Aza-Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan
Funder
Ministry of Education, Culture, Sports, Science, and Technology
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/ol502633j
Reference36 articles.
1. Isolation and characterization of new 18-membered macrolides FD-891 and FD-892.
2. Structures of new 18-membered macrolides FD-891 and FD-892.
3. Stereostructure of a Novel Cytotoxic 18-Membered Macrolactone Antibiotic FD-891
4. Structure Revision of FD-891, a 16-Membered Macrolide Antibiotic
5. FD-891, a structural analogue of concanamycin A that does not affect vacuolar acidification or perforin activity, yet potently prevents cytotoxic T lymphocyte-mediated cytotoxicity through the blockage of conjugate formation
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