Development of a Scalable Synthesis of (S)-3-Fluoromethyl-γ-butyrolactone, Building Block for Carmegliptin’s Lactam Moiety-Reference-Cited by-同舟云学术

Development of a Scalable Synthesis of (S)-3-Fluoromethyl-γ-butyrolactone, Building Block for Carmegliptin’s Lactam Moiety

Published:2011-05-05 Issue:3 Volume:15 Page:515-526
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Adam Jean-Michel¹,Foricher Joseph¹,Hanlon Steven¹,Lohri Bruno¹,Moine Gérard¹,Schmid Rudolf¹,Stahr Helmut¹,Weber Martin¹,Wirz Beat¹,Zutter Ulrich¹

Affiliation:

1. F. Hoffmann-La Roche Ltd., Pharmaceuticals Division, †pRED, Pharma Research and Early Development, Process Research and Synthesis, and ‡Pharma Technical Development Actives, Grenzacherstrasse 124, CH-4070 Basel, Switzerland

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op200019k

Reference46 articles.

1. Discovery of carmegliptin: A potent and long-acting dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

2. Aryl- and heteroaryl-substituted aminobenzo[a]quinolizines as dipeptidyl peptidase IV inhibitors

3. An Efficient Process for the Manufacture of Carmegliptin

4. aAbrecht, S.; Adam, J.M.; Fettes, A.; Foricher, J.; Lohri, B.; Mattei, P.; Moine, G.; Schmid, R.; Zutter, U.(F. Hoffmann-La Roche AG). PCT Int. Appl. WO 2006/125728 A1, 2006.

5. bZutter, U.(F. Hoffmann-La Roche Inc.). U.S. Pat. Appl. Publ. U.S. 2008/108816 A1, 2008.

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