Promiscuous Aggregate-Based Inhibitors Promote Enzyme Unfolding-Reference-Cited by-同舟云学术

Promiscuous Aggregate-Based Inhibitors Promote Enzyme Unfolding

Published:2009-03-12 Issue:7 Volume:52 Page:2067-2075
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Coan Kristin E. D.¹,Maltby David A.¹,Burlingame Alma L.¹,Shoichet Brian K.¹

Affiliation:

1. Department of Pharmaceutical Chemistry & Graduate Group in Chemistry and Chemical Biology, University of California—San Francisco, Byers Hall, 1700 4th Street, San Francisco, California 94158-2550, Mass Spectrometry Facility, Department of Pharmaceutical Chemistry, University of California—San Francisco, 600 16th Street, MC 2240, Genentech Hall, Suite N472A, San Francisco, California 94158-2517

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm801605r

Reference39 articles.

1. High-throughput assays for promiscuous inhibitors

2. A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening

3. Specificity and mechanism of action of some commonly used protein kinase inhibitors

4. Concentration and pH Dependent Aggregation of Hydrophobic Drug Molecules and Relevance to Oral Bioavailability

5. Inhibition of voltage-dependent sodium channels by Ro 31-8220, a ‘specific’ protein kinase C inhibitor

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