Syntheses and Characterization of the Acyl Glucuronide and Hydroxy Metabolites of Diclofenac-Reference-Cited by-同舟云学术

Syntheses and Characterization of the Acyl Glucuronide and Hydroxy Metabolites of Diclofenac

Published:2004-04-27 Issue:11 Volume:47 Page:2816-2825
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kenny Jane R.¹,Maggs James L.¹,Meng Xiaoli¹,Sinnott Deborah¹,Clarke Stephen E.¹,Park B. Kevin¹,Stachulski Andrew V.¹

Affiliation:

1. Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool L69 3GE, United Kingdom, Robert Robinson Laboratories, Department of Chemistry, University of Liverpool, Liverpool L69 7ZD, United Kingdom, and Department of Mechanism and Extrapolation, GlaxoSmithKline, The Frythe, Ware, Hertfordshire AL6 9AR, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm030891w

Reference44 articles.

1. Synthesis and quantitative structure-activity relationships of diclofenac analogs

2. The history of diclofenac

3. Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

4. Idiosyncratic Liver Toxicity of Nonsteroidal Antiinflammatory Drugs: Molecular Mechanisms and Pathology

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