Disubstituted Bis-THF Moieties as New P2 Ligands in Nonpeptidal HIV-1 Protease Inhibitors
Author:
Affiliation:
1. School of Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ, United Kingdom
2. Tibotec, Turnhoutseweg 30, 2340 Beerse, Belgium
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/ml2000356
Reference20 articles.
1. AIDS — The First 20 Years
2. Active human immunodeficiency virus protease is required for viral infectivity.
3. Structure-Based Design of HIV-1 Protease Inhibitors: Replacement of Two Amides and a 10.pi.-Aromatic System by a Fused Bis-tetrahydrofuran
4. Discovery and Selection of TMC114, a Next Generation HIV-1 Protease Inhibitor
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