Overall Synthesis of GSK356278: Quick Delivery of a PDE4 Inhibitor Using a Fit-for-Purpose Approach-Reference-Cited by-同舟云学术

Overall Synthesis of GSK356278: Quick Delivery of a PDE4 Inhibitor Using a Fit-for-Purpose Approach

Published:2010-07-01 Issue:5 Volume:14 Page:1153-1161
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Guercio Giuseppe¹,Castoldi Damiano¹,Giubellina Nicola¹,Lamonica Alessandro¹,Ribecai Arianna¹,Stabile Paolo¹,Westerduin Pieter¹,Dams Riet¹,Nicoletti Anna¹,Rossi Sara¹,Bismara Claudio¹,Provera Stefano¹,Turco Lucilla¹

Affiliation:

1. Synthetic Chemistry, Analytical Science, PPSE, Technical Sourcing Group, Chemical Development Department, and Analytical Chemistry, GlaxoSmithKline Medicines Research Centre, Via Fleming 4, Verona, Italy

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op1001148

Reference17 articles.

1. Signal transduction abnormalities in melancholic depression

2. Protein kinase a in postmortem brain of depressed suicide victims: altered expression of specific regulatory and catalytic subunits

3. Regulation of phosphodiesterase-4 (PDE4) expression in mouse brain by repeated antidepressant treatment: Comparison with rolipram

4. Signaling Pathways Regulating Gene Expression, Neuroplasticity, and Neurotrophic Mechanisms in the Action of Antidepressants: A Critical Overview

Cited by 8 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Sources, sustainability and directions in the chemical synthesis of δ-aminolevulinic acid;Sustainable Chemistry and Pharmacy;2024-04

2. Discovery of New 1,4,6-Trisubstituted-1H-pyrazolo[3,4-b]pyridines with Anti-Tumor Efficacy in Mouse Model of Breast Cancer;Pharmaceutics;2023-02-27

3. 1H-Pyrazolo[3,4-b]pyridines: Synthesis and Biomedical Applications;Molecules;2022-03-30

4. One-pot three-component synthesis of novel pyrazolo[3,4-b]pyridines as potent antileukemic agents;European Journal of Medicinal Chemistry;2022-01

5. Quantification of human brain PDE4 occupancy by GSK356278: A [11C](R)-rolipram PET study;Journal of Cerebral Blood Flow & Metabolism;2017-07-24