Abstract
Pyrazolo[3,4-b]pyridines are a group of heterocyclic compounds presenting two possible tautomeric forms: the 1H- and 2H-isomers. More than 300,000 1H-pyrazolo[3,4-b]pyridines have been described which are included in more than 5500 references (2400 patents) up to date. This review will cover the analysis of the diversity of the substituents present at positions N1, C3, C4, C5, and C6, the synthetic methods used for their synthesis, starting from both a preformed pyrazole or pyridine, and the biomedical applications of such compounds.
Funder
Ministerio de Ciencia, Innovación y Universidades
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
Reference147 articles.
1. Bicyclic 5-6 Systems: Three Heteroatoms 2:1;Buckley,2008
2. New Compound Obtained by the Action of Iodine on Benzalphenylhydrazone in Pyridine Solution;Ortoleva;Gazz. Chim. Ital.,1908
3. Synthesis of Derivatives of 1,2,7-Pyrazopyridine. A New Variety of Homo-(C. C)-Condensed, Bisheterocyclic Compounds;Bulow;Ber. Dtsch. Chem. Ges.,1911
4. Scifinder, Version 2019,2019
5. Synteesis of Certain C-4 Substituted Pyrazolo[3,4-b]-Pyridine Nucleosides Structurally Related to Adenosine and Inosine by Tee Sodiw Salt Glycosylation Procedure
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