Design and Synthesis of m1-Selective Muscarinic Agonists: (R)-(−)-(Z)-1-Azabicyclo[2.2.1]heptan-3-one, O-(3-(3‘-Methoxyphenyl)-2-propynyl)- oxime Maleate (CI-1017), a Functionally m1-Selective Muscarinic Agonist-Reference-Cited by-同舟云学术

Design and Synthesis of m1-Selective Muscarinic Agonists: (R)-(−)-(Z)-1-Azabicyclo[2.2.1]heptan-3-one, O-(3-(3‘-Methoxyphenyl)-2-propynyl)- oxime Maleate (CI-1017), a Functionally m1-Selective Muscarinic Agonist

Published:1998-06-04 Issue:14 Volume:41 Page:2524-2536
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Tecle Haile¹,Barrett Stephen D.¹,Lauffer David J.¹,Augelli-Szafran Corinne¹,Brann Mark R.¹,Callahan Michael J.¹,Caprathe Bradley. W.¹,Davis Robert E.¹,Doyle Patricia D.¹,Eubanks David¹,Lipiniski William¹,Mirzadegan Tara¹,Moos Walter H.¹,Moreland D. W.¹,Nelson Carrie B.¹,Pavia Michael R.¹,Raby Charlotte¹,Schwarz Roy D.¹,Spencer Carolyn J.¹,Thomas Anthony J.¹,Jaen Juan C.¹

Affiliation:

1. Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, Michigan 48106-1047, and Receptor Technologies, Inc., Winooski, Vermont 05404

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm960683m

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4. Physostigmine and Arecoline: Effects of Intravenous Infusions in Alzheimer Presenile Dementia

5. Measurement of cholinergic drug effects on memory in alzheimer's disease

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