Cutting into the Substrate Dominance: Pharmacophore and Structure-Based Approaches toward Inhibiting Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H-Reference-Cited by-同舟云学术

Cutting into the Substrate Dominance: Pharmacophore and Structure-Based Approaches toward Inhibiting Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H

Published:2019-12-27 Issue:1 Volume:53 Page:218-230
ISSN:0001-4842
Container-title:Accounts of Chemical Research
language:en
Short-container-title:Acc. Chem. Res.

Author:

Wang Lei¹^ORCID,Sarafianos Stefan G.²^ORCID,Wang Zhengqiang³^ORCID

Affiliation:

1. State Key Laboratory of Fine Chemicals, Department of Pharmacy, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, China

2. Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, United States

3. Center for Drug Design, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, United States

Funder

National Institute of Allergy and Infectious Diseases

University of Minnesota

Publisher

American Chemical Society (ACS)

Subject

General Medicine,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.accounts.9b00450

Reference61 articles.

1. Azidothymidine

2. U.S. Food and Drug Administration. Antiretroviral drugs used in the treatment of HIV infection, April 12, 2018. www.fda.gov.

3. Update on HAART in HIV

4. Structure and Function of HIV-1 Reverse Transcriptase: Molecular Mechanisms of Polymerization and Inhibition

5. HIV-1 Ribonuclease H: Structure, Catalytic Mechanism and Inhibitors

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