Design, synthesis and biological evaluation of Thiazolo[3, 2-a]Pyrimidine derivatives as novel RNase H inhibitors-Reference-Cited by-同舟云学术

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Design, synthesis and biological evaluation of Thiazolo[3, 2-a]Pyrimidine derivatives as novel RNase H inhibitors

Published:2024-07 Issue: Volume:148 Page:107495
ISSN:0045-2068
Container-title:Bioorganic Chemistry
language:en
Short-container-title:Bioorganic Chemistry

Author:

Zhao Ke-Xin,Zhang Yi-Ying,Wang Jin-Si,Wang Shuai,Corona Angela,Maloccu Stefania,Tramontano Enzo,Pannecouque Christophe,De Clercq Erik,Meng Ge,Wang Lei,Chen Fen-Er

Publisher

Elsevier BV

Reference27 articles.

1. Structure-Based optimization of 2,4,5-trisubstituted pyrimidines as potent HIV-1 non-nucleoside reverse transcriptase inhibitors: Exploiting the tolerant regions of the non-nucleoside reverse transcriptase inhibitors’ binding pocket;Zhao;J. Med. Chem.,2023

2. Insights into HIV-1 reverse transcriptase (RT) inhibition and drug resistance from thirty years of structural studies;Singh;Viruses,2022

3. Designing safer CRISPR/Cas9 therapeutics for HIV: Defining factors that regulate and technologies used to detect off-target editing;Sullivan;Front. Microbiol.,2020

4. Adverse effects of antiretroviral therapy;Carr;Lancet,2000

5. Pre-existing minority drug-resistant HIV-1 variants, adherence, and risk of antiretroviral treatment failure;Paredes;J. Infect. Dis.,2010

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