1. Discovery DMPK and Bioanalytical Chemistry, AstraZeneca R&D Mölndal, SE-431 83 Mölndal, Sweden, Department of Chemistry, Medicinal Chemistry, Göteborg University, SE-412 96 Gothenburg, Sweden, Lead Molecular Design, S.L., Vallés 96-102 (27) E-08190, Sant Cugat del Vallés, Spain, and Institut Municipal d'Investigació Medica (IMIM), Universitat Pompeu Fabra, Doctor Aiguader 80, 08003 Barcelona, Spain