Synthesis, in Vitro Covalent Binding Evaluation, and Metabolism of 14C-Labeled Inhibitors of 11β-HSD1-Reference-Cited by-同舟云学术

Synthesis, in Vitro Covalent Binding Evaluation, and Metabolism of 14C-Labeled Inhibitors of 11β-HSD1

Published:2014-09-30 Issue:11 Volume:5 Page:1245-1250
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Sun Daqing¹,Ye Qiuping¹,Yan Xuelei¹,Rew Yosup¹,Fan Peter¹,He Xiao¹,Jiang Min¹,McMinn Dustin L.¹,Monshouwer Mario¹,Tu Hua¹,Powers Jay P.¹

Affiliation:

1. Departments of Therapeutic Discovery, ‡Metabolic Disorders, and §Pharmacokinetics and Drug Metabolism, Amgen, Inc., 1120 Veterans Boulevard, South San Francisco, California 94080, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ml500331y

Reference23 articles.

1. 11β-Hydroxysteroid dehydrogenase and the pre-receptor regulation of corticosteroid hormone action

2. Inhibition of 11β-HSD1 as a novel treatment for the metabolic syndrome: do glucocorticoids play a role?

3. Novel Adipose Tissue–Mediated Resistance to Diet-Induced Visceral Obesity in 11β-Hydroxysteroid Dehydrogenase Type 1–Deficient Mice

4. 11β-Hydroxysteroid Dehydrogenase Type 1: A Tissue-Specific Regulator of Glucocorticoid Response

5. Cushing's syndrome

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