Kinetic Mechanism for the Flipping and Excision of 1,N6-Ethenoadenine by AlkA
Author:
Affiliation:
1. Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States
Funder
National Institute of General Medical Sciences
Publisher
American Chemical Society (ACS)
Subject
Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/bi501356x
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1. Instability and decay of the primary structure of DNA
2. Endogenous generation of reactive oxidants and electrophiles and their reactions with DNA and protein
3. Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents
4. Repairing DNA-methylation damage
5. Catalytic Promiscuity and the Divergent Evolution of DNA Repair Enzymes
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