Resistance-Guided Mining of Bacterial Genotoxins Defines a Family of DNA Glycosylases-Reference-Cited by-同舟云学术

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Resistance-Guided Mining of Bacterial Genotoxins Defines a Family of DNA Glycosylases

Published:2022-04-26 Issue:2 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Bradley Noah P.¹,Wahl Katherine L.¹,Steenwyk Jacob L.¹^ORCID,Rokas Antonis¹²^ORCID,Eichman Brandt F.¹³^ORCID

Affiliation:

1. Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, USA

2. Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

3. Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

Abstract

Bacteria are rich sources of secondary metabolites that include DNA-damaging genotoxins with antitumor/antibiotic properties. AlthoughStreptomycesproduce a diverse number of therapeutic genotoxins, efforts toward targeted discovery of biosynthetic gene clusters (BGCs) producing DNA-damaging agents is lacking.

Funder

HHS | National Institutes of Health

Howard Hughes Medical Institute

National Science Foundation

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03297-21

Reference88 articles.

1. Microbial drug discovery: 80 years of progress

2. Antibiotics produced by Streptomyces

3. Unpackaging the Roles of Streptomyces Natural Products

4. Anticancer Drug Discovery from Microbial Sources: The Unique Mangrove Streptomycetes

5. The Ecological Role of Volatile and Soluble Secondary Metabolites Produced by Soil Bacteria

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1. An interstrand DNA crosslink glycosylase aids Acinetobacter baumannii pathogenesis;Proceedings of the National Academy of Sciences;2024-06-26

2. Strategies of N-Glycosidic Bond Cleavage by DNA Repair Enzymes;Moscow University Chemistry Bulletin;2024-04

3. STRATEGIES OF N-GLYCOSIDIC BOND CLEAVAGE BY DNA REPAIR ENZYMES;Lomonosov chemistry journal;2024-02-26

4. Biosynthesis of DNA-Alkylating Antitumor Natural Products;Molecules;2022-09-27

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