Synthesis, Characterization, and Structure−Activity Relationships of Amidine-Substituted (Bis)benzylidene-Cycloketone Olefin Isomers as Potent and Selective Factor Xa Inhibitors-Reference-Cited by-同舟云学术

Synthesis, Characterization, and Structure−Activity Relationships of Amidine-Substituted (Bis)benzylidene-Cycloketone Olefin Isomers as Potent and Selective Factor Xa Inhibitors

Published:1999-12-01 Issue:26 Volume:42 Page:5415-5425
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Guilford William J.¹,Shaw Kenneth J.¹,Dallas Jerry L.¹,Koovakkat Sunil¹,Lee Wheeseong¹,Liang Amy¹,Light David R.¹,McCarrick Margaret A.¹,Whitlow Marc¹,Ye Bin¹,Morrissey Michael M.¹

Affiliation:

1. Discovery Research, Berlex Biosciences, 15049 San Pablo Avenue, P.O. Box 4099, Richmond, California 94804-0099

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm990456v

Reference39 articles.

1. A communication introducing this material has been published: Shaw, K. J.; Guilford, W. J.; Dallas, J. L.; Koovakaat, S. K.; McCarrick, M. A.; Liang, A.; Light, D. R.; Morrissey, M. M. (Z,Z)-2,7-Bis-(4-amidinobenzylidene)-cycloheptan-1-one: identification of a highly active inhibitor of blood coagulation factor Xa.J. Med. Chem.1998,41, 3551−3556.

2. Importance of factor Xa in determining the procoagulant activity of whole-blood clots.

3. Role of Thrombin Compared With Factor Xa in the Procoagulant Activity of Whole Blood Clots

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